Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways

Table 2 Criteria for stage allocation and distribution of cases^a

	Motor cortex	Brainstem	Sensory cortex/ striatum	Hippocampus	Number of cases
Stage 1	+	-	-	-	1 (3 %)
Stage 2	+	+	-	-	8 (24 %)
Stage 3	+	+	+	-	16 (47 %)
Stage 4^a	+	+	+	+	9 (26 %)

^a Note three cases had pTDP-43 pathology observed in the hippocampus consistent with Stage 4 ALS

ISSN: 2051-5960