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Table 2 Criteria for stage allocation and distribution of casesa

From: Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways

  Motor cortex Brainstem Sensory cortex/ striatum Hippocampus Number of cases
Stage 1 + - - - 1 (3 %)
Stage 2 + + - - 8 (24 %)
Stage 3 + + + - 16 (47 %)
Stage 4a + + + + 9 (26 %)
  1. a Note three cases had pTDP-43 pathology observed in the hippocampus consistent with Stage 4 ALS