Skip to main content

Table 1 Summary of neuronal loss and semi-quantitative assessment of tau pathology in different brain regions

From: Neuropathology of Beta-propeller protein associated neurodegeneration (BPAN): a new tauopathy

Brain regions Neuronal loss Tau pathology
Threads Pre-tangles Neurofibrillary tangles
Cortex
Frontal + +++ - ++
Temporal + +++ - ++
Parietal + +++ - ++
Occipital Infarct visual cortex + - -
Cingulate - +++ - +++
Sub-cortical white matter
Frontal N/A + N/A N/A
Temporal N/A + N/A N/A
Parietal N/A + N/A N/A
Occipital N/A + N/A N/A
Cingulate N/A ++ N/A N/A
Amygdala - +++ - +++
Hippocampus
Dentate fascia - + - ++
CA4 - ++ + ++
CA3 - ++ - ++
CA2 - ++ - ++
CA1 - +++ + +++
Subiculum - +++ + +++
Entorhinal cortex - +++ + +++
Transentorhinal cortex - +++ + +++
Caudate - +++ + ++
Putamen - ++ + ++
Globus pallidus + ++ - +
Meynert + +++ - +++
Thalamus - ++ - ++
Subthalamic nucleus - ++ - ++
Substantia nigra +++ ++ - +
Locus coeruleus + ++ - +
Pontine tegmentum - ++ - ++
Pontine nuclei - + - +
Dorsal motor nucleus of vagus - + - +
Twelfth nerve nucleus - + - -
Inferior olive - + - -
Gracile nucleus - + - -
Cuneate nucleus - + - -
Cerebellar Purkinje cells + - - -
Cerebellar white matter N/A - N/A N/A
Dentate nucleus - + - +
  1. N/A not applicable