Table 1 Summary of neuronal loss and semi-quantitative assessment of tau pathology in different brain regions
From: Neuropathology of Beta-propeller protein associated neurodegeneration (BPAN): a new tauopathy
Brain regions | Neuronal loss | Tau pathology | ||
|---|---|---|---|---|
Threads | Pre-tangles | Neurofibrillary tangles | ||
Cortex | ||||
Frontal | + | +++ | - | ++ |
Temporal | + | +++ | - | ++ |
Parietal | + | +++ | - | ++ |
Occipital | Infarct visual cortex | + | - | - |
Cingulate | - | +++ | - | +++ |
Sub-cortical white matter | ||||
Frontal | N/A | + | N/A | N/A |
Temporal | N/A | + | N/A | N/A |
Parietal | N/A | + | N/A | N/A |
Occipital | N/A | + | N/A | N/A |
Cingulate | N/A | ++ | N/A | N/A |
Amygdala | - | +++ | - | +++ |
Hippocampus | ||||
Dentate fascia | - | + | - | ++ |
CA4 | - | ++ | + | ++ |
CA3 | - | ++ | - | ++ |
CA2 | - | ++ | - | ++ |
CA1 | - | +++ | + | +++ |
Subiculum | - | +++ | + | +++ |
Entorhinal cortex | - | +++ | + | +++ |
Transentorhinal cortex | - | +++ | + | +++ |
Caudate | - | +++ | + | ++ |
Putamen | - | ++ | + | ++ |
Globus pallidus | + | ++ | - | + |
Meynert | + | +++ | - | +++ |
Thalamus | - | ++ | - | ++ |
Subthalamic nucleus | - | ++ | - | ++ |
Substantia nigra | +++ | ++ | - | + |
Locus coeruleus | + | ++ | - | + |
Pontine tegmentum | - | ++ | - | ++ |
Pontine nuclei | - | + | - | + |
Dorsal motor nucleus of vagus | - | + | - | + |
Twelfth nerve nucleus | - | + | - | - |
Inferior olive | - | + | - | - |
Gracile nucleus | - | + | - | - |
Cuneate nucleus | - | + | - | - |
Cerebellar Purkinje cells | + | - | - | - |
Cerebellar white matter | N/A | - | N/A | N/A |
Dentate nucleus | - | + | - | + |