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Table 2 Clinical information and regional specific binding of 3H-THK5117 on autoradiography sections from the three Alzheimer cases

From: Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue

Demographic data
Demography AD Case 1 AD Case 2 AD Case 3
  Onset EOAD LOAD LOAD
  Gender (M/F) F F M
  ApoE alleles (E/E) 4/4 4/4 4/4
  MMSE at time of last PET 12 26 25
  Age at death (years) 60 79 81
  Time between last PET and death (years) 7 7 5
3H-THK5117 specific binding in regions of interest (fmol/mg)
Regions of interest AD Case 1 AD Case 2 AD Case 3
  Hippocampus 693 171 112
  Entorhinal cortex 713 126 53
  Fusiform gyrus 585 189 52
  Inferior temporal gyrus 764 125 59
  Middle temporal gyrus 495 140 48
  Superior temporal gyrus 363 114 53
  Insular cortex 423 68 50
  Postcentral gyrus 312 77 75
  Precentral gyrus 310 32 102
  Middle frontal gyrus 276 55 56
  Superior frontal gyrus 344 57 114
  Cingulate gyrus 292 120 110
  Putamen 242 NA NA
  Thalamus 349 NA NA
  Amygdala 507 NA NA
  1. 3H-THK5117 binding values were obtained by subtracting the nonspecific binding values from the total binding values. Regions of interest were defined for each case by manual segmentation of the section
  2. AD = Alzheimer’s Disease; EOAD = Early Onset Alzheimer’s Disease; LOAD = Late Onset Alzheimer’s Disease; M = male; F = Female; NA = not available