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Table 2 Clinical information and regional specific binding of 3H-THK5117 on autoradiography sections from the three Alzheimer cases

From: Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue

Demographic data

Demography

AD Case 1

AD Case 2

AD Case 3

  Onset

EOAD

LOAD

LOAD

  Gender (M/F)

F

F

M

  ApoE alleles (E/E)

4/4

4/4

4/4

  MMSE at time of last PET

12

26

25

  Age at death (years)

60

79

81

  Time between last PET and death (years)

7

7

5

3H-THK5117 specific binding in regions of interest (fmol/mg)

Regions of interest

AD Case 1

AD Case 2

AD Case 3

  Hippocampus

693

171

112

  Entorhinal cortex

713

126

53

  Fusiform gyrus

585

189

52

  Inferior temporal gyrus

764

125

59

  Middle temporal gyrus

495

140

48

  Superior temporal gyrus

363

114

53

  Insular cortex

423

68

50

  Postcentral gyrus

312

77

75

  Precentral gyrus

310

32

102

  Middle frontal gyrus

276

55

56

  Superior frontal gyrus

344

57

114

  Cingulate gyrus

292

120

110

  Putamen

242

NA

NA

  Thalamus

349

NA

NA

  Amygdala

507

NA

NA

  1. 3H-THK5117 binding values were obtained by subtracting the nonspecific binding values from the total binding values. Regions of interest were defined for each case by manual segmentation of the section
  2. AD = Alzheimer’s Disease; EOAD = Early Onset Alzheimer’s Disease; LOAD = Late Onset Alzheimer’s Disease; M = male; F = Female; NA = not available