Fig. 3

Axonal spheroids were heterogeneously distributed throughout the subcortical white matter across all three subjects. Lateral representations display the relative burden of the subcortical white matter spheroid pathology as density measurements for Cases #1-3 that are mapped to different cortical regions (a-c respectively). Densities of the APP positive spheroids were obtained from counts and surface areas generated by white matter regions of interest in NIH’s ImageJ 1.49. Dark grey areas indicate regions where densities were not obtained