Fig. 1From: Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degenerationRepresentative images of DPR inclusions. a-j are representative immunofluorescence confocal images of DPR (red) and TDP-43 (green) (scale bar = 20 μm). a-e show cytoplasmic DPR inclusions, which are often perinuclear. f-h show nuclear DPR inclusions. i and j show evidence of DPR inclusions colocalizing with TDP-43. k and l are lower power images of the anterior horn showing the relative abundance of DPR and TDP-43 inclusions (scale bar = 50 μm). l shows a poly-GA inclusion, which is not in the motor neurons (dotted nucleus) that show extensive cytoplasmic TDP deposition. k shows a poly-GP inclusion within a motor neuron (identified by its large pale nucleus), which does not show cytoplasmic TDP-43 inclusions. Motor neurons were identified by their characteristic large pale nucleus (dotted line)Back to article page