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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration

Fig. 1

Representative images of DPR inclusions. a-j are representative immunofluorescence confocal images of DPR (red) and TDP-43 (green) (scale bar = 20 μm). a-e show cytoplasmic DPR inclusions, which are often perinuclear. f-h show nuclear DPR inclusions. i and j show evidence of DPR inclusions colocalizing with TDP-43. k and l are lower power images of the anterior horn showing the relative abundance of DPR and TDP-43 inclusions (scale bar = 50 μm). l shows a poly-GA inclusion, which is not in the motor neurons (dotted nucleus) that show extensive cytoplasmic TDP deposition. k shows a poly-GP inclusion within a motor neuron (identified by its large pale nucleus), which does not show cytoplasmic TDP-43 inclusions. Motor neurons were identified by their characteristic large pale nucleus (dotted line)

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