Fig. 3
From: Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
Epitope masking effects of β1 antibody treatment in the frontocentral cortex of APP23 mice. Epitope modification after anti-Aβ (β1) antibody treatment in 11-month-old APP23 mice. Although an antibody raised against Aβ1–17 (6E10) exhibited similar levels of Aβ plaques (a, b - arrows) as provided by the respective Aβ (6E10) plaque load (c) the β1 antibody used for treatment detected less plaques in the treated animals than in the PBS-controls (d, e - arrows) as confirmed by a significantly lowered β1 plaque load (f). Less plaques were also detected with B10AP antibody fragments detecting protofibril/ fibril-specific epitopes (g, h - arrows) with respective changes in the B10AP plaque load (i). Graphs c, f, and i represent mean values (symbols) and standard errors (whiskers), * p < 0.05 (Statistical analysis in Additional file 3: Table S3). Calibration bar in a (valid for a, b, d, e, g, h) = 280 μm