Fig. 1

Degeneration of commissural neurons with a highly ramified dendritic tree: Effects of β1 antibody treatment. a, b Layer III type 1 commissural neurons in the frontocentral cortex traced with DiI. The detectable type 1 commissural neurons did not show significant differences between PBS- and β1-treated APP23 mice even at 5 months of age. c The number of the type 1 commissural neurons in 5-month-old β1 treated mice was higher than that in PBS-treated animals whereas no such differences were observed for type 2 and 3 commissural neurons. d No differences in the numbers of DiI-traced type 1–3 commissural neurons were seen among 11-month-old PBS- and β1-treated APP23 mice. Graphs represent mean values (symbols) and standard errors (whiskers), * p < 0.05 (Statistical analysis in Additional file 3: Table S3). Calibration bar in b (valid for a, b) = 37.5 μm