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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

Fig. 6

Co-expression of TDP-43WT and TDP-43Q331K in mice results in a loss of pyramidal neurons from the layer V region of the motor and somatosensory cortex. (a-d) Cresyl violet staining of cells in the layer V region of the cortex of young NTg (a), TDP-43WT (b), TDP-43Q331K (c) and TDP-43WTxQ331K (d) mice, showing a dearth of large pyramidal neurons in TDP-43WTxQ331K animals, together with a mild reduction in TDP-43Q331K mice. e Cell counting of large pyramidal cells in the cortex showed a significant loss of approximately 28 % of large pyramidal neurons in TDP-43WTxQ331K mice compared with age matched non-transgenic and TDP-43WT animals. Young TDP-43Q331K single transgenic animals showed a mild, non-significant loss of approximately 12 % of pyramidal cells. (* p < 0.05 vs age-matched NTg and TDP-43WT animals)

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