Fig. 5

Co-expression of TDP-43^WT and TDP-43^Q331K in mice results in ubiquitin and p62 positive TDP-43 inclusions in the layer V region of the motor and somatosensory cortex. a Small TDP-43 inclusions were present in large pyramidal cells from the layer 5 region of the motor and somatosensory cortices of TDP-43^WTxQ331K mice (arrows), accompanied by ubiquitin (b) and p62 (c) aggregates (scale bar: 10 μm). Fluorescent co-labelling of myc-TDP and ubiquitin (d) or p62 (e) in the motor cortex of TDP-43^WTxQ331K animals shows aggregates that are positive for both myc-TDP and p62/ubiquitin (arrows), together with myc-TDP negative, p62 inclusions (arrowheads). (scale bar : 10 μm)