Table 3 Enriched ontology terms associated with ACP-exclusive genes. Limma identified 384 genes that were exclusively expressed in ACP compared to a normal brain tissues and a variety of CNS and peripheral malignancies. DAVID was used to identify 23 enriched ontologies (FDR < 0.005) that are shown ranked according to fold enrichment. Abbreviation: Ontology ID prefix GO, Gene ontology biological process; BP, panther biological process; HSA, KEGG pathway; FDR, Benjamini false discovery rate adjusted p-value
From: Identification of targets for rational pharmacological therapy in childhood craniopharyngioma
Ontology term | ID | Fold enrichment | p-Value | FDR |
|---|---|---|---|---|
Biomineral formation | GO:31214 | 13.38 | 2.53E-07 | 5.50E-05 |
Odontogenesis of dentine-containing tooth | GO:42475 | 11.28 | 5.50E-06 | 8.69E-04 |
Epidermis development | GO:8544 | 11.06 | 3.10E-27 | 2.70E-24 |
Ectoderm development | GO:7398 | 10.78 | 2.62E-28 | 4.55E-25 |
Epidermal cell differentiation | GO:9913 | 9.17 | 6.27E-08 | 1.56E-05 |
Keratinocyte differentiation | GO:30216 | 9.17 | 2.74E-07 | 5.29E-05 |
Odontogenesis | GO:42476 | 9.17 | 5.23E-06 | 9.09E-04 |
Epithelial cell differentiation | GO:30855 | 8.43 | 5.25E-13 | 3.04E-10 |
Skeletal development | BP:201 | 5.81 | 7.85E-07 | 1.96E-05 |
Epithelium development | GO:60429 | 5.57 | 1.46E-10 | 6.33E-08 |
Bone development | GO:60348 | 5.37 | 1.42E-05 | 0.00205 |
Ossification | GO:1503 | 5.26 | 4.46E-05 | 0.00515 |
Cell structure | BP:286 | 3.72 | 2.38E-14 | 2.98E-12 |
Cell adhesion-mediated signaling | BP:120 | 3.66 | 4.34E-08 | 1.36E-06 |
Cytokine-cytokine receptor interaction | HSA:4060 | 3.38 | 5.13E-05 | 0.00557 |
Skeletal system development | GO:1501 | 3.28 | 2.06E-05 | 0.00274 |
Cell structure and motility | BP:285 | 2.85 | 2.68E-13 | 1.68E-11 |
Cell adhesion | GO:7155 | 2.83 | 4.39E-08 | 1.52E-05 |
Biological adhesion | GO:22610 | 2.82 | 4.48E-08 | 1.30E-05 |
Cell communication | BP:274 | 2.46 | 6.08E-10 | 2.53E-08 |
Cell adhesion | BP:124 | 2.30 | 1.57E-04 | 0.00280 |
Regulation of cell proliferation | GO:42127 | 2.24 | 3.69E-05 | 0.00457 |
Signal transduction | BP:102 | 1.43 | 1.21E-04 | 0.00251 |