Fig. 1
From: Identification of targets for rational pharmacological therapy in childhood craniopharyngioma
Gene expression of potential targets for therapeutic intervention in ACP. Expression of the indicated genes in ACP relative to a broad range of pediatric and adult brain tumor types: atypical teratoid/rhabdoid tumor (AT/RT), choroid plexus papilloma (CPP), ependymoma (EPN), glioblastoma multiforme (GBM), medulloblastoma (MED), meningioma (MEN), pilocytic astrocytoma (PA), primitive neuroectodermal tumor (PNET); peripheral pediatric solid tumors: malignant peripheral nerve sheath tumors (MPNST), rhabdomyosarcoma (RMS); in addition to malignant (pituitary adenoma) and normal pituitary (PT and N_P respectively); and normal brain and choroid plexus (N_B and N_CP respectively). Dasatinib targets, LCK (lymphocyte-specific protein tyrosine kinase), EPHA2 (ephrin type-A receptor 2) and SRC (SRC proto-oncogene, non-receptor tyrosine kinase) (a). Sonic hedgehog homolog (b). Matrix metalloproteases 9 & 12 (c). EGF pathway genes (d). Values are expressed as log2 gene expression. Horizontal red bars represent the mean, and error bars represent standard error of the mean (SEM)