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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

Fig. 7

Tau4RTg2652 animals have impaired spatial memory abilities. (a) Tau4RTg2652 mice take longer to locate and enter the escape box on all days of testing at all ages. Data shown are the mean of each animal’s daily average performance in the Barnes maze (2 trials per day). Error bars show the standard error of the mean. WT animals shown as open circles, Tau4RTg2652 animals shown as solid squares. For planned comparisons of genotypes on each testing day: *: p < 0.05 **: p < 0.01 ***p < 0.001 (b) Spontaneous interictal spike and seizure recorded in bilateral screw electrodes from one of the homozygous mice studied. The electrographic seizures recorded were correlated with the behavioral seizures witnessed via the video-EEG recordings

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