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Table 1 Summary of clinical findings of patients with multiple system atrophy (MSA)

From: Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

Case No. Age at death (years) Gender Disease duration (years) Clinical diagnosis Pathological diagnosis Initial symptoms Symptoms
Parkinsonian signs Cerebellar signs OH UD Constipation Dyshidrosis Impotence
1 49 F 7 MSA-P MSA-P limping + + + +
2 57 F 1 spinocerebellar degeneration MSA-C ataxia +
3 58 M 7 SDS MSA-C UD, constipation, impotence + + + + + +
4 61 M 7 MSA-P MSA-P UD + + + +
5 61 F 4.5 MSA-P MSA-P tremor + + + +
6 63 F 3 MSA-P MSA-P gait disturbance + + +
7 65 M 7 MSA-C MSA-C gait disturbance + + + +
8 65 M 14 MSA-C MSA-P gait disturbance + + + +
9 66 M 9 SDS MSA-P UD + + + + +
10 66 M 13 MSA-C MSA-C sensory disturbance + + + + +
11 69 M 8 SDS MSA-C snoring + + + +
12 71 F <1 neurologically normal MSA-C none
13 75 M 8 progressive supranuclear palsy MSA-P gait disturbance + + + +
14 79 M 4 SDS MSA-C unsteady gait + + +
  1. OH, orthostatic hypotension; UD, urogenital dysfunction; SDS, Shy-Drager syndrome; +, present;−, absent