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Table 1 Summary of clinical findings of patients with multiple system atrophy (MSA)

From: Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

Case No.

Age at death (years)

Gender

Disease duration (years)

Clinical diagnosis

Pathological diagnosis

Initial symptoms

Symptoms

Parkinsonian signs

Cerebellar signs

OH

UD

Constipation

Dyshidrosis

Impotence

1

49

F

7

MSA-P

MSA-P

limping

+

+

+

+

2

57

F

1

spinocerebellar degeneration

MSA-C

ataxia

+

3

58

M

7

SDS

MSA-C

UD, constipation, impotence

+

+

+

+

+

+

4

61

M

7

MSA-P

MSA-P

UD

+

+

+

+

5

61

F

4.5

MSA-P

MSA-P

tremor

+

+

+

+

6

63

F

3

MSA-P

MSA-P

gait disturbance

+

+

+

7

65

M

7

MSA-C

MSA-C

gait disturbance

+

+

+

+

8

65

M

14

MSA-C

MSA-P

gait disturbance

+

+

+

+

9

66

M

9

SDS

MSA-P

UD

+

+

+

+

+

10

66

M

13

MSA-C

MSA-C

sensory disturbance

+

+

+

+

+

11

69

M

8

SDS

MSA-C

snoring

+

+

+

+

12

71

F

<1

neurologically normal

MSA-C

none

13

75

M

8

progressive supranuclear palsy

MSA-P

gait disturbance

+

+

+

+

14

79

M

4

SDS

MSA-C

unsteady gait

+

+

+

  1. OH, orthostatic hypotension; UD, urogenital dysfunction; SDS, Shy-Drager syndrome; +, present;−, absent