Fig. 2
From: Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica
A. Behavioral assessment of adoptive intravenous transfer of T cells from AQP4 null mice immunized against loop C peptide of AQP4. The Behavior Score is a 5 point EAE-scale scoring the extent of neurologic disability (0 is no disability, 5 is death). Wildtype mice (triangles) adoptively transferred with cultured AQP4-restimulated, Th17 polarized AQP4-reactive T cells develop weakness in the tail and hind limbs (EAE score of 1.0–2.0, n = 4). Transfer of AQP4-reactive T cells that are not re-stimulated with AQP4 peptide (squares, n = 5) or stimulated with non-specific proteins (circles, n = 6) show no behavioral phenotype. B. Daily weights show typical weight loss in mice receiving the Th17 polarized AQP4-reactive and AQP4-restimulated T cells (triangles), but not in mice that receive unstimulated (circles) or non-AQP4-specifically re-stimulated T cells (squares)