Figure 3

Spatial learning of MB-treated Tau^ΔK mice. Morris water maze (MWM) acquisition shows spatial learning abilities as indicated by path lengths (cm) of mice after MB application using different preventive and therapeutic treatment paradigms. Significant group differences are observed between untreated Tau^ΔK mice and WT animals throughout all experiments, demonstrating impaired learning abilities upon expression of pro-aggregant Tau (a-c). By contrast Tau^ΔK mice treated with MB for 14.5mo (a) and 6mo (b) behave comparable to controls indicating preservation of cognitive functions. Short-term MB treatment for 3mo has no beneficial impact on the learning performance of Tau^ΔK mice (c). Data shows mean path length ± SEM. Statistics: two-way repeated measure analysis of variances with post hoc Fishers LSD multiple comparisons test. Asterisks indicate differences between MB-treated and untreated Tau^ΔK mice; *: p < 0.05; n: number of mice.