Exploration behavior of MB-treated TauΔK mice. Total activity (%) within 15 min is analyzed by an open field test after various MB treatment periods. (a) Preventive MB treatment for (a) 14.5mo and for (b) 6mo results in preservation of exploration behavior of TauΔK mice similar to wild-type (WT) animals, whereas untreated TauΔK mice show a significantly reduced activity. By contrast no group-differences are observed after therapeutic MB treatment for 3mo (c). Bars represent mean values ± SEM. Statistics: one-way analysis of variances with post-hoc Newman-Keuls multiple comparisons test. Asterisks indicate significant differences between groups; *: p < 0.05; **: p < 0.01; mo: months.