Figure 2

MYC amplified medulloblastoma cell lines show differential expression of class I HDACs HDAC1, 2 and 3. a gene expression as measured by quantitative RT-real time PCR shows differential expression of HDAC1, 2 and 3 in medulloblastoma cell lines with high MYC expression, with HDAC2 showing a significant difference between MYC amplified and MYC non-amplified cell lines (* = p < 0.05, one way ANOVA test). b protein detection by western blot detects higher cMYC and HDAC2 protein in cells with MYC amplification. c correlation of HDAC2 and MYC mRNA expression as measured by gene expression profiling in n = 42 primary Group 3 MB tumors (Pearson product-moment correlation coefficient, two tailed p-test). Bars depict mean and standard error of three independent experiments.