Figure 9

PGC-1α prevents oxidative stress induced by aSyn in vivo. (a) Immunostaining for HNE, a marker for oxidative damage, at 6 months after co-injection of PGC1α-KO mice with an AAV2/6 vector encoding aSyn and a control non-coding vector (NCV). Note the presence of the HNE staining in the SNpc of PGC1α-KO mice expressing aSyn. (b) Co-injection with AAV2/6 vectors encoding aSyn and PGC-1α. Note that PGC-1α overexpression suppresses signs of oxidative stress in PGC1α-KO mice expressing aSyn. The non-injected side (NInj) is shown for comparison. Scale bar: 100 μm.