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Table 1 List of antibodies that are selected based on their ability to detect TDP-43 pathology, reported multiple times

From: TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

Antibody (Epitope/Immunogen)

Manufacturer/First report

Clonality

Species

Times reported with scores 1-1

Times reported with scores 0 1 or 1-0

Times reported with scores 0-0

Total times scored (n = 104)

1D3 (pS409/410, AA 403–414/P)

Millipore/Neumann 2009

mono

rat

3

-

-

3

TIP-PTD-P05 (pS403/404; AA 398–408/P)

Cosmo Bio/Hasegawa 2008

poly

rabbit

5

1

-

6

TIP-PTD-M01 (pS409/410; AA 405–414/P)

Cosmo Bio/Inukai 2008

mono

mouse

7

2

-

9

TIP-PTD-P01&-P02 (pS409/410; AA 405–414/P)

Cosmo Bio/Hasegawa 2008

poly

rabbit

12

5

-

17

1039C/C-t TDP-43 (AA 394–414/P)

Igaz 2008

poly

rabbit

5

2

2

9

10782 (AA 203–209 and AA near N-terminus/R)

ProteinTech

poly

rabbit

14

9

2

25

2E2-D3 (AA 205–222/R)

Abnova, Novus, Abcam, etc.

mono

mouse

12

8

4

24

12892 (AA 288–414/R)

ProteinTech

poly

rabbit

3

2

1

6

TIP-TD-P09 (AA 405–414/P)

Cosmo Bio/Hasegawa 2008

poly

rabbit

1

2

-

3

MC2085 (AA 220–227/P)

Zhang 2009

poly

rabbit

-

2

-

2

  1. Antibodies are ordered by percentage of double positive reports. Immunogen is depicted as P = peptide immunogen or R = recombinant protein immunogen. Bold italic antibodies are those which are considered “standard” when studying TDP-43.