Figure 2
From: IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity
IFNβ/YFP producing cells localize to active lesions in the CNS at the peak of disease. a On day 17 after EAE induction spinal cord was isolated from IFNβmob/mob mice. Histological analysis of lesions in the spinal cord of IFNβmob/mob mice at peak disease. Spinal cord sections were stained with luxol fast blue for the detection of demyelination and nuclear fast red for visualization of cellular infiltrates. Arrows indicate cellular infiltrates. gm: grey matter. wm: white matter. Scale bar represents 200 μm. b IFNβ/YFP producing cells localize to lesions in the spinal cord of MOG-immunized IFNβmob/mob mice at d17. IFNβ/YFP+ cells were stained with a YFP-crossreacting anti-GFP antibody. Dashed lines mark the area of cell infiltrates indicating lesions. Scale bar represents 50 μm.