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Table 3 Predicted protein conformational changes due to p.P112H TARDBP mutation

From: A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques

PolyPhen-2

SIFT

SNAP

Prediction

Score a

Prediction

Score b

Prediction

Expected accuracy c

Probably damaging

0.999

Affects protein function

0.01

Non-neutral

87%

  1. aThe lower score, the more benign the substitution. bThe higher score, the more tolerated the change is expected to be. Scores <0.05 are predicted to be deleterious. cThe higher the percentage, the greater the confidence of the prediction.