PolyPhen-2
|
SIFT
|
SNAP
|
---|
Prediction
|
Score
a
|
Prediction
|
Score
b
|
Prediction
|
Expected accuracy
c
|
Probably damaging | 0.999 | Affects protein function | 0.01 | Non-neutral | 87% |
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aThe lower score, the more benign the substitution. bThe higher score, the more tolerated the change is expected to be. Scores <0.05 are predicted to be deleterious. cThe higher the percentage, the greater the confidence of the prediction.