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Table 2 Longitudinal neuropsychological and functional assessments of the index patient

From: A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques

 

Maximum score

1st evaluation ( 2008 )

2nd evaluation ( 2009 )

3rd evaluation ( 2010 )

Global cognition

    

MMSE

30

29

27

7

Memory

    

CVLT trials

9-9-9-9

5-8-9-9

6-7-7-7

NA-

CVLT inmediate recall (30”)

9

9

4

-

CVLT delayed recall (10’)

9

9

3

-

CVLT recognition

9

9

9

-

Modified Rey-Osterrieth figure recall

17

10

4

-

Language

    

BNT

15

11

8

-

PPVT-R

16

14

12

 

Visuospatial

    

Modified Rey-Osterrieth figure copy

17

16

16

-

VOSP (Number location)

10

9

9

-

Face matching

12

12

9

-

Executive function

    

Digit span forward

-

6

6

-

Digit span backward

-

7

7

-

Modified trials

-

29”

39”

-

Stroop interference

-

49

-

-

Semantic verbal fluency

-

14

9

-

Phonemic verbal fluency

-

13

13

-

Figure design fluency

-

8

8

-

Functional assessment

    

Barthel index

100

100

75

30

CDR total (Sum of boxes)

3 (18)

1 (5.5)

1 (6)

3 (18)

  1. BNT: Boston Naming Test; CDR: Clinical Dementia Rating Scale; CVLT: California Verbal Learning Test; MMSE: Mini-Mental State Examination; PPVT-R: Peabody Picture Vocabulary Test Revised; VOSP: Visual Object and Space Perception Battery.