Figure 5

Atypical 4R- tauopathy of the proband and patient 2. Left column (a, c) immunostaining for 4R-tau, and right column (b, d), immunostaining for 3R-tau. All sections are from entorhinal cortex. (a and b) proband showing 4R-tau glial inclusions, threads and few neuronal tangles in entorhinal cortex (a); only a neurofibrillary tangles (arrow) is 3R-tau-positive pathology in the same area (b). The same features are seen in patient 2 (c, d) to a lesser extent. Scale bars: 10 μm.