Figure 4From: A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques Histopathological features of the proband and patient 2. Right column (a, d) immunostaining for beta-amyloid (4G8), middle column (b , e), immunostaining for phospho-tau (CP-13), and left column (c, f) Gallays silver staining. (a, b) proband showing abundant neuritic plaques including cored plaques in angular gyrus. The plaques are negative for phospho-tau, in contrast to those seen in Alzheimer’s disease. Despite the lack of phospho-tau, the silver staining confirm the plaques’ neuritic nature (c). (d- f) The same features are seen in the middle frontal gyrus of patient 2. Scale bars: 40 μm.Back to article page