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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques

Figure 4

Histopathological features of the proband and patient 2. Right column (a, d) immunostaining for beta-amyloid (4G8), middle column (b , e), immunostaining for phospho-tau (CP-13), and left column (c, f) Gallays silver staining. (a, b) proband showing abundant neuritic plaques including cored plaques in angular gyrus. The plaques are negative for phospho-tau, in contrast to those seen in Alzheimer’s disease. Despite the lack of phospho-tau, the silver staining confirm the plaques’ neuritic nature (c). (d- f) The same features are seen in the middle frontal gyrus of patient 2. Scale bars: 40 μm.

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