Figure 3

Pathological TDP -43 inclusions in the index and patient 2. (a) inferior temporal gyrus shows abundant neuronal cytoplasmic inclusions, some threads and intranuclear inclusions (* and insert). (b) orbitofrontal cortex of the same patient showing similar features. (c) ventral striatum of patient 2 depicting neuronal cytoplasmic inclusions and few threads. (d) inferior temporal gyrus of patient 2. The neuronal cytoplasmic inclusions present in different shapes, either compact (arrow) or granular (arrowhead) in nature. Inclusions are found throughout the cortical layers. Scale bars: 10 μm.