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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation

Figure 2

Intracellular AT1 in neural and vascular cells of the adult human substantia nigra. AT1 is shown to be highly expressed in nigral dopamine neurons (A), in Iba1-positive microglia (B), and in S100B- (C) and GFAP-immunoreactive astrocytes (D-G) of a 69 years old prePD patient. AT1 is also detected in vascular smooth muscle cells in the tunica media (i.e., the medial layer) of the blood vessel wall (C). Scale bars are 20 μm.

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