Table 1 Synopsis of cases
From: Early neurone loss in Alzheimer’s disease: cortical or subcortical?
Control | Alzheimer’s disease | |||||
|---|---|---|---|---|---|---|
Preclinical AD | Prodromal AD/MCI | AD mild dementia | AD moderate dementia | AD severe dementia | ||
Number of cases | 19 | 18 | 13 | 18 | 22 | 30 |
Gender: male/female | 8/11 | 7/11 | 6/7 | 8/10 | 9/13 | 12/18 |
Age in years (+/-SD) | 81.3 +/- 4.4 | 79.9 +/- 6.5 | 80.2 +/- 5.4 | 81.4 +/- 5.9 | 83.6 +/- 5.8 | 83.4 +/- 6.8 |
CDR | ||||||
0 | 19 | 18 | ||||
0.5 | 13 | |||||
1 | 18 | |||||
2 | 22 | |||||
3 | 30 | |||||
NFT stage* | ||||||
0 | 19 | |||||
1 | 18 | 6 | ||||
2 | 7 | 6 | 4 | |||
3 | 12 | 18 | 30 | |||
Aß/amyloid plaque score* | ||||||
0 | 19 | |||||
1 | 18 | 5 | ||||
2 | 8 | 4 | 2 | |||
3 | 14 | 20 | 30 | |||
CERAD* | ||||||
0 | 19 | |||||
1 | 18 | 4 | ||||
2 | 9 | 5 | 2 | |||
3 | 13 | 20 | 30 | |||
ABC score* | ||||||
Not | 19 | |||||
Low | 18 | 7 | ||||
Intermediate | 6 | 6 | 4 | |||
High | 12 | 18 | 30 | |||
Cause of death | ||||||
Bronchopneumonia | 5 | 15 | 10 | 12 | 16 | 25 |
Myocardial infarction | 8 | |||||
Congestive heart failure | 1 | 1 | 1 | 2 | ||
Embolism of lung | 3 | 3 | 1 | 2 | 1 | 2 |
Sepsis | 1 | 2 | 3 | 1 | ||
Lung cancer | 1 | 1 | ||||
Pancreatic cancer | 1 | |||||
Breast cancer | 1 | |||||
Renal failure | 1 | |||||
Postmortem delay in h (+/-SD) | 3.4 +/- 0.6 | 3.8 +/- 0.7 | 4.1 +/- 0.5 | 3.5 +/- 0.6 | 3.7 +/- 0.7 | 3.6 +/- 0.8 |
Fresh brain weight in gm (+/-SD) | 1278 +/- 76 | 1258 +/- 51 | 1245 +/- 86 | 1212 +/- 56 | 1183 +/- 64 | 1150 +/- 103 |
Phospho-tau (mab AT8) positive pathology | ||||||
Ncl basalis of Meynert | 0 | 18 | 13 | 18 | 22 | 30 |
Locus coeruleus | 0 | 18 | 13 | 18 | 22 | 30 |
Entorhinal cort. Layer II | 0 | 18 | 13 | 18 | 22 | 30 |
Aß (mab 6E10) positive pathology | ||||||
Ncl basalis of Meynert | 0 | 0 | 8 | 18 | 22 | 30 |
Locus coeruleus | 0 | 0 | 0 | 14 | 20 | 30 |
Entorhinal cort. Layer II | 0 | 6 | 10 | 18 | 22 | 30 |