Figure 8
From: Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
Effects of tau suppression on tau and Hsp27 levels. Quantification of relative tau (H-150) levels in the (a and b) hippocampus (± SEM) and (c and d) frontal cortex (± SEM) of DOX-treated 12-month old rTg4510 mice compared to 9- and 12-month old untreated rTg4510 mice; representative images are shown. Scale bar in cortical images represents 100 μm. *** p <0.001 Scale bar in hippocampal images represents 200 μm; inset scale bar represents 50 μm. Relative levels of Hsp27 in the (e and f) hippocampus (± SEM) and (g and h) frontal cortex (± SEM) from 12-month old DOX-treated mice compared to 9- and 12-month old mice, relative to wild-type controls; representative images are shown. Scale bar represents 20 μm. ** p <0.01, *** p <0.001.