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Figure 7 | Acta Neuropathologica Communications

Figure 7

From: Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

Figure 7

Tau suppression by DOX slows BBB defect in 12-month old rTg4510 mice. IgG levels in the (a and b) hippocampus (± SEM) and (c and d) frontal cortex (± SEM) of 12-month old DOX-treated mice compared to 9- and 12-month old wild-type and rTg4510 mice; Representative images are shown. *** p <0.001, ** p <0.01. Scale bar represents 200 μm. Images of e whole brains immediately following perfusion to observe Evans blue (EB) (black arrowhead) in 12 month DOX-treated mice compared to 9 and 12 month old rTg4510 relative to matching wild-type mice. Scale bar represents 200 μm. Positive EB expression was measured in the (f and g) hippocampus (± SEM) and (h and i) frontal cortex (± SEM) of 12 month old DOX-treated mice compared to 9- and 12-month old rTg4510 and age-matched wild-type mice; representative images of 9-month old, 12-month old, and DOX-treated 12-month old mice are shown. * p <0.05**, p <0.01. Scale bar represents 50 μm. Relative j hippocampal brain volume (± SEM) in 9- and 12-month old rTg4510 mice compared to 12-month old rTg4510 mice treated with DOX. *** p <0.001.

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