Figure 5
From: Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
GFAP positive astrocytes accumulate with age in rTg4510 mice. Area ratio positive for GFAP immunoreactivity was quantified in the a hippocampus (± SEM) (*p = 0.01696; ***p <0.001) and b frontal cortex (± SEM) (6-month *p = 0.020102, 9 month *p = 0.04813, ***p <0.001) of wild-type and rTg4510 mice at 6, 9 and 12 months of age; c representative whole brain images are shown. Scale bar represents 2000 μm. Representative images of d hippocampus (± SEM) and e cortex (± SEM) of GFAP immunostained tissue from 6-, 9- and 12-month old wild-type and rTg4510 mice. Scale bar represents 100 μm; inset scale represents 20 μm.