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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

Figure 2

Evans blue (EB) extravasation reveals blood-brain barrier dysfunction in rTg4510 mice by 12 months of age. Representative images of whole brains immediately following perfusion displayed gross a EB extravasation (black arrowhead) in 9- and 12-month old rTg4510 mice. Scale bar represents 200 μm. Representative 20x images of b EB fluorescence in the CA1, CA3, dentate gyrus (DG), frontal cortex (CTX), entorhinal cortex (ECTX), striatum (STR), and hippocampal commissure (HC) of 12-month old wild-type and 6-, 9-, and 12-month old rTg4510 mice. Scale bar represents 50 μm. Representative whole brain image stained with c anti-mouse IgG from 12-month oldwild-type and rTg4510 mice showing map of locations used for EB fluorescent imaging in b. Scale bar represents 2000 um. Quantification of EB fluorescence in the d hippocampus (± SEM) of 6-, 9-, and 12-month old rTg4510 and wild-type mice. ***p <0.001, ** p <0.01. Quantification of EB fluorescence in the frontal cortex (± SEM) e of 6-, 9-, and 12-month old rTg4510 and wild-type mice. *** p <0.001, ** p <0.05.

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