Figure 10
From: Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
Tau accumulates along hippocampal blood vessels in 12-month old rT4510 mice. 20x magnification image of the a hippocampus of a 12-month old rTg4510 mouse stained with tau (H-150) to show the region of perivascular tau accumulation. Scale bar represents 100 μm. Relative levels of b tau (H-150) (± SEM) were measured in and around the longitudinal hippocampal blood vessels in 9- and 12-month old and 12-month old rTg4510 mice treated with DOX. ***p <0.001. Representative images of tau (H-150) stained tissue from a c 12-month wild-type mouse and rTg4510 mice at d 6, e 9, and f 12 months of age, and g 12-month old rTg4510 mice DOX-treated mice are shown. Scale bars represent 50 μm.