Figure 1
From: Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
IgG accumulates with age in the rTg4510 mouse model. a Goat anti-mouse IgG staining on tissue from 1-, 3-, 9-, and 12-month old rTg4510 and wild-type (WT) mice. Arrows indicate areas of most intense IgG accumulation in the frontal cortex and hippocampus. Scale bar represents 2000 μm. Quantification of the relative area ratio of IgG accumulation in the b hippocampus (± SEM). ** p <0.01, ***p < 0.001. 5× magnification of the c hippocampus of 3-, 9-, and 12-month old rTg4510 and wild-type mice showing progressive accumulation of IgG in the hippocampus with age. Arrow indicates CA3 area has more IgG accumulation. Scale bar represents 200 μm. Quantification of the relative area ratio of IgG accumulation in the d frontal cortex (± SEM) of rTg4510 compared to wild-type mice with age. ***p < 0.001. 5x magnification of the e frontal cortex of 3-, 9-, and 12-month old rTg4510 and wild-type mice showing progressive accumulation of IgG in the cortex with age. Arrow highlights the most accumulation of IgG is on the surface of the cortex. Scale bar represents 200 μm.