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Table 3 Comparison of correlation between UPDRS motor scores and CSF pS129 levels, overall and stratified by disease duration

From: Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity

  DATATOP baseline DATATOP final Multi-center collaborative LRRK2
N Corr P N Corr P N Corr P N Corr P
pS129 Whole cohort 95 −0.244 0.017 95 0.147 0.834 199 0.147 0.038 30 −0.050 0.794
Disease duration ≤2 years 69 −0.289 0.016 18 −0.093 0.712 32 0.043 0.817 --   
Disease duration >2 years 23 −0.067 0.778 74 −0.050 0.674 164 0.173 0.027 --   
  1. B: baseline time point. F: final time point. Most LRRK2 cohort subjects have not yet received PD diagnoses. Disease durations not available for 3 DATATOP subjects and 3 multi-center collaborative cohort subjects.
  2. Bold font indicates significance at the p=0.05 level.