Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity

Table 3 Comparison of correlation between UPDRS motor scores and CSF pS129 levels, overall and stratified by disease duration

		DATATOP baseline			DATATOP final			Multi-center collaborative			LRRK2
		N	Corr	P	N	Corr	P	N	Corr	P	N	Corr	P
pS129	Whole cohort	95	−0.244	0.017	95	0.147	0.834	199	0.147	0.038	30	−0.050	0.794
	Disease duration ≤2 years	69	−0.289	0.016	18	−0.093	0.712	32	0.043	0.817	--
	Disease duration >2 years	23	−0.067	0.778	74	−0.050	0.674	164	0.173	0.027	--

B: baseline time point. F: final time point. Most LRRK2 cohort subjects have not yet received PD diagnoses. Disease durations not available for 3 DATATOP subjects and 3 multi-center collaborative cohort subjects.
Bold font indicates significance at the p=0.05 level.

ISSN: 2051-5960