LRRK2 subjects with greater brain pathology have lower CSF pS129. A) Significant decrease in TBZ scores in subjects with PD diagnoses. B. Relationship between TBZ scores and pS129 in LRRK2 mutation carriers. Note that x-axis is inverted to facilitate comparison with UPDRS measurements in Figure 2. Dotted regression lines represent whole cohort; solid lines represent cohort excluding subjects with TBZ scores ≥1. Black triangles: Subjects without PD diagnosis and TBZ < 1. Open triangles: Subjects with no diagnosis and TBZ > 1. Circles: Subjects with PD diagnosis and UPDRS motor scores < 20.