The relationship between pS129 and motor symptoms changes with disease severity. pS129 and UPDRS motor scores by disease duration A) Relationship between CSF pS129 and UPDRS motor scores in subjects in DATATOP and cross-sectional cohorts. Line is Loess curve for combined datasets including multi-center collaborative cohort and DATATOP baseline and final time points. B)-E) Relationship between pS129 and UPDRS in cohort subsets divided by disease stage. B) DATATOP DD less than 2 years. C) DATATOP DD greater than 2 years. D) Cross-sectional DD less than 2 years. D) Cross-sectional DD greater than 2 years. MC: Multi-center collaborative cohort. DD: Disease duration, time since diagnosis in years. DB: DATATOP baseline time point. DF: DATATOP final time point. Diamonds: multi-center collaborative cohort. Black circles: DATATOP baseline. Gray circles: DATATOP final.