Longitudinal changes in pS129 and relationship with total α-syn. A) Change in pS129 by baseline level. Triangles: subjects that did not reach endpoint. Squares: subjects that reached endpoint. Solid line: regression line generated from all subjects combined. B) Association between total α-syn and pS129 levels by time point. Circles: baseline time point. Squares: final time point. Lines represent correlation between total α-syn and pS129 for each time point.