From: Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid
 | Autism patients with no seizure disorder | Autism patients with seizure disorder | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | AN01093 (A1) | AN00764 (A3) | AN00493 (A6) | UMB1182 (A9) | AN06420 (A5) | UMB797 (A8) | AN08873 (A7) | UMB1174 (A2) | AN08792 (A4) | AN16641 (A10) | AN16615 (A11) |
TrkB-FL | −2.0 SD | −1.5 SD | −2.0 SD | −1.5 SD | 0.5 SD | −0.5 SD | 0.5 SD | −2.0 SD | −2.0 SD | −1.5 SD | −1.5 SD |
PI3K p85 | −2.0 SD | −1.5 SD | −2.0 SD | −2.0 SD | 0.5 SD | −0.5 SD | 0.5 SD | −2.0 SD | −2.0 SD | 1.5 SD | −1.5 SD |
Akt | −2.0 SD | −0.5 SD | −1.5 SD | −2.0 SD | 1.5 SD | −0.5 SD | 0.5 SD | −1.5 SD | −1.5 SD | −0.5 SD | −1.5 SD |
mTOR | −2.0 SD | −2.0 SD | −2.0 SD | −2.0 SD | 1.5 SD | −0.5 SD | 0.5 SD | −2.0 SD | −2.0 SD | −1.5 SD | −2.0 SD |
Phospho-mTOR | −1.5 SD | −2.0 SD | −2.0 SD | −2.0 SD | 0.5 SD | −0.5 SD | −0.5 SD | −2.0 SD | −2.0 SD | −2.0 SD | −2.0 SD |
p70 S6 Kinase | −2.0 SD | −1.5 SD | −1.5 SD | −2.0 SD | 0.5 SD | −0.5 SD | −0.5 SD | −1.5 SD | −2.0 SD | −1.5 SD | −1.5 SD |
eIF4B | −2.0 SD | −2.0 SD | −2.0 SD | −1.5 SD | 1.5 SD | 2.0 SD | −0.5 SD | −1.5 SD | −2.0 SD | −2.0 SD | −2.0 SD |
PSD-95 | −1.5 SD | −1.5 SD | −1.5 SD | −1.5 SD | 0.5 SD | 0.5 SD | 0.5 SD | −1.5 SD | −1.5 SD | −1.5 SD | −1.5 SD |