Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

Table 1 Characteristics of autism tissue samples

Sample ID#	CASE #	Age (years)	Gender	PMI (hours)	Primary cause of death	ADI-R	Drug treatment history
A1	AN01093	56	Male	19.48	Anoxic Encephalopathy	48	N/A
A2	UMB1174	7	Female	14	Seizure, Hypotension	44	Depakote, Dilantin, Tegretol
A3	AN00764	20	Male	23.7	Auto Trauma	50	Minocin
A4	AN08792	30	Male	20.3	GastroIntestinal Bleeding	41	Phenobarbital, Mysoline, Dilantin, Depakote, Cisapride, Clorazepate, Prolosec, Propulsid, Reglan, Tranxene
A5	AN06420	39	Male	13.95	Cardiac Tamponade	41	Synthroid, Depakote, Risperidol, Paxil, Blood pressure medication
A6	AN00493	27	Male	8.3	Drowning	-	Synthroid
A7	AN08873	5	Male	25.5	Asphyxia Due To Drowning	47	Prozac
A8	UMB797	9	Male	13	Drowning	50	Desipramine
A9	UMB1182	9	Female	24	Smoke Inhalation	-	N/A
A10	AN16641	9	Male	27	Seizure Disorder	46	Clonidine, Depakote, Dilantin, Lamictal, Ritalin, Tegretol
A11	AN16115	11	Female	12.88	Seizure & Drowning in Tub	44	Adderall, Dexadrine, Dilantin, Klonopin, Lamictal, Tegretol, Topomax
	Mean	20.1		18.3
	SEM (+/−)	4.9		1.8

N/A = Information Not Available; PMI = Post Mortem Interval; ADI-R = Autism Diagnostic Interview-Revised.

ISSN: 2051-5960