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Table 3 Trajectory of neuronal nucleus volume changes throughout the lifespan of autistic and control subjects

From: Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults

Brain region Autism Control
A B C Diff % P value Diff % P value A B C Diff % P value Diff % P value
4–8 y 11–23 y 36–60 y A/B A/C 4–8 y 14–23 y 29–64 y A/B A/C
Nucleus accumbens 163 213 253 31% 0.911 55% 0.904 281 226 239 −20% 0.001 −15% 0.001
Purkinje cells 394 552 654 40% 0.226 66% 0.468 575 561 569 −2% 0.000 −1 0.402
Claustrum 233 255 307 9% 0.081 32% 0.000 395 360 267 −9% 0.001 −32 0.000
Thalamus 371 433 581 17% 0.533 57% 0.000 645 439 462 −32% 0.000 −28% 0.000
Globus pallidus 503 479 489 −5% 0.357 −3% 0.000 625 417 478 −33% 0.001 −24% 0.000
Dentate nucleus 305 489 501 60% 0.257 64% 0.000 510 448 397 −12% 0.269 −22% 0.008
Entorhinal cortex 408 444 484 9% 0.857 19% 0.007 561 502 452 −10% 0.632 −19.6% 0.000
Amygdala 431 520 498 21% 0.140 16% 0.732 606 595 548 −2% 0.001 −10% 0.026
Magnocellular basal complex 476 581 611 22% 0.000 28% 0.030 656 575 558 −12% 0.000 −15% 0.064
Putamen 180 231 223 28% 0.332 24% 0.830 246 244 213 −1% 0.019 −13% 0.007
Caudate nucleus 181 234 234 29% 0.374 29% 0.812 256 229 182 −11% 0.003 −29% 0.000
Inferior olive 507 553 551 9% 0.089 9% 0.000 613 525 508 −14% 0.000 −17% 0.150
Magnocellular LGN 382 483 567 26% 0.405 48% 0.002 455 457 502 0 0.255 10% 0.189
Parvocellular LGN 217 263 335 21% 0.578 54% 0.000 268 264 284 −1% 0.503 6% 0.436
Substantia nigra 756 816 685 8% 0.911 −9% 0.035 815 811 646 0% 0.367 −21% 0.002
Ammon’s horn 576 631 706 9% 0.509 23% 0.888 702 702 683 0% 0.316 −3% 0.000
  1. Significance levels computed controlling for post-mortem interval, days of fixation, days of dehydration, and weight loss. Results were non-significant using a false discovery rate (FDR) of p < 0.05. A/B and A/C not bootstrapped p-value.