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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease

Figure 4

Abnormal lysosomal activity in the absence of LAMP-2 expression. (a) Immunoblots and respective densitometric quantification of cathepsin D (CtD) in wild-type (WT) or LAMP-2-deficient (LAMP-2-/y) brain lysates (data are shown as the mean; protein levels were normalized to actin, asterisk highlights a non-specific band recognized by the used cathepsin D antibody and p (premature), i (intermediate) and m (mature) denote the different forms of cathepsin D). (b/c) Regional specific activity of (b) β-hexosaminidase and (c) β-glucuronidase in wild-type and LAMP-2-/y brain lysates (Hip, hippocampus; Cx, cortex; Cblm, cerebellum; #p > 0.05, *p < 0.05).

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