Figure 2
From: Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
2HG concentration is higher in mIDH1-GL261 than pGL261-gliomas. a, b Representative spectra show variation of brain metabolite concentration measured at the injection site of gliomas from mIDH1-GL261 compared to controls. Data were acquired before cell injection (pre-injection), and 8 days after tumor implantation. c 2HG concentration increased in mIDH1-GL261 gliomas at day 8 and decreased on day 20 possibly as a consequence of a decreased expression of IDH1 as evaluated by RT-PCR on explanted gliomas (Figure 1l). d Intratumoral 2HG measured at day 30 showed higher levels in mIDH1-GL261 than in pGL261-gliomas.