Figure 1

SC express and internalize TTR in the Hsf/V30M FAP mouse model. A) Representative picture of double immunofluorescence between TTR (green) and Oct-6 (red) in Hsf/V30M nerves, demonstrating TTR intracellular staining in SC (arrows). Superposition of the labels, with DAPI (blue), is shown (merge, n = 4). Scale bar 10 μm. B) Double immunofluorescence of TTR (green) and EEA1 (red) demonstrating colocalization between the 2 proteins in SC of Hsf/V30M mice (arrows). Scale bar 5 μm. C) Confocal representative image of a sciatic nerve section stained with anti-TTR antibody (green) and a lysosome marker (Lamp1; red). Colocalization between both markers was noticed in yellow; scale bar 5 μm.