Models of α-synuclein aggregation in Parkinson’s disease

Table 1 Overview of LB-like formation in rodent models. Brain areas with the presence of DA receptors and LB-like and/or LN-like aggregates may suggest an interaction between the dopaminergic system and α-syn (see text)

Brain Nucleus	Braak’s stage	PrP-A53T-α-syn mice		Rotenone in rats		Smad3 null mice		DA system
X-XII	1	+++	LB- LN					Yes
OB	1	++	LB-LN					Yes
sp5	2	++	LN			++	LN	Yes
ll	2					++	LN	Yes
Sc	2	++++	LB-LN			++	LB	Yes
RF/LC	2	+++	LB- LN			++	LN	Yes
RN	2, 3	+++	LB-LN					Yes
VTA	3	+	LB- LN			++	LN	Yes
CPu	3	++	LB- LN	+++++	LB- LN	++++	LN	Yes
SN	3	+	LB- LN	+++++	LB- LN	+++++	LN	Yes
Hp	3,4					++++	LB-LN	Yes
Th	4	+++	LB-LN					Yes
M1-M2	5,6					++++	LB-LN	Yes
Cg	5,6					+++	LN	Yes
cc-ic-cp	--					+++	LN
Pn	--					++	LB	Yes
CB	--	++++	LB-LN			++	LN	Yes
Pir	--					+++	LN	Yes
IC	--	+++	LB-LN
SC	--	+++	LB-LN					Yes

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