From: Models of α-synuclein aggregation in Parkinson’s disease

Brain Nucleus | Braak’s stage | PrP-A53T-α-syn mice | Rotenone in rats | Smad3 null mice | DA system | |||
---|---|---|---|---|---|---|---|---|

X-XII | 1 | +++ | LB- LN | Yes | ||||

OB | 1 | ++ | LB-LN | Yes | ||||

sp5 | 2 | ++ | LN | ++ | LN | Yes | ||

ll | 2 | ++ | LN | Yes | ||||

Sc | 2 | ++++ | LB-LN | ++ | LB | Yes | ||

RF/LC | 2 | +++ | LB- LN | ++ | LN | Yes | ||

RN | 2, 3 | +++ | LB-LN | Yes | ||||

VTA | 3 | + | LB- LN | ++ | LN | Yes | ||

CPu | 3 | ++ | LB- LN | +++++ | LB- LN | ++++ | LN | Yes |

SN | 3 | + | LB- LN | +++++ | LB- LN | +++++ | LN | Yes |

Hp | 3,4 | ++++ | LB-LN | Yes | ||||

Th | 4 | +++ | LB-LN | Yes | ||||

M1-M2 | 5,6 | ++++ | LB-LN | Yes | ||||

Cg | 5,6 | +++ | LN | Yes | ||||

cc-ic-cp | -- | +++ | LN | |||||

Pn | -- | ++ | LB | Yes | ||||

CB | -- | ++++ | LB-LN | ++ | LN | Yes | ||

Pir | -- | +++ | LN | Yes | ||||

IC | -- | +++ | LB-LN | |||||

SC | -- | +++ | LB-LN | Yes |