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Table 1 Overview of LB-like formation in rodent models. Brain areas with the presence of DA receptors and LB-like and/or LN-like aggregates may suggest an interaction between the dopaminergic system and α-syn (see text)

From: Models of α-synuclein aggregation in Parkinson’s disease

Brain Nucleus Braak’s stage PrP-A53T-α-syn mice Rotenone in rats Smad3 null mice DA system
X-XII 1 +++ LB- LN      Yes
OB 1 ++ LB-LN      Yes
sp5 2 ++ LN    ++ LN Yes
ll 2      ++ LN Yes
Sc 2 ++++ LB-LN    ++ LB Yes
RF/LC 2 +++ LB- LN    ++ LN Yes
RN 2, 3 +++ LB-LN      Yes
VTA 3 + LB- LN    ++ LN Yes
CPu 3 ++ LB- LN +++++ LB- LN ++++ LN Yes
SN 3 + LB- LN +++++ LB- LN +++++ LN Yes
Hp 3,4      ++++ LB-LN Yes
Th 4 +++ LB-LN      Yes
M1-M2 5,6      ++++ LB-LN Yes
Cg 5,6      +++ LN Yes
cc-ic-cp --      +++ LN  
Pn --      ++ LB Yes
CB -- ++++ LB-LN    ++ LN Yes
Pir --      +++ LN Yes
IC -- +++ LB-LN      
SC -- +++ LB-LN      Yes