Skip to main content

Table 3 Intrinsic properties, spontaneous and miniature EPSCs, and paired pulse facilitation (PPF) of AMPA receptor-mediated evoked EPSCs were not significantly disrupted in hippocampal slices from pre-plaque 3.5-5 month-old McGill-Thy1-APP TG rats

From: Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

  WT TG
Intrinsic Properties (n = 7, 9 cells) (n = 6, 14 cells)
(3.5-5 months)
Resting membrane −61.6 ± 2.1 −63.8 ± 1.7
potential (mV)
τ membrane (ms) 14.3 ± 1.0 15.1 ± 1.0
Sag Ratio 0.9 ± 0.01 0.9 ± 0.01
sEPSCs (n = 5, 6 cells) (n = 9, 9 cells)
(4–4.5 months)
Amplitude (pA) −14.3 ± 1.1 −12.8 ± 1.0
Frequency (Hz) 3.5 ± 1.5 2.4 ± 0.6
mEPSCs (n = 5, 6 cells) (n = 9, 9 cells)
(4–4.5 months)
Amplitude (pA) −12.1 ± 1.1 −11.3 ± 1.1
Frequency (Hz) 1.2 ± 0.4 1.1 ± 0.3
AMPA EPSCs (n = 15, 23 cells) (n = 25, 44 cells)
(3.5-5 months)
PPF (ratio) 50 ms IPI 1.4 ± 0.1 1.5 ± 0.04