Table 3 Intrinsic properties, spontaneous and miniature EPSCs, and paired pulse facilitation (PPF) of AMPA receptor-mediated evoked EPSCs were not significantly disrupted in hippocampal slices from pre-plaque 3.5-5 month-old McGill-Thy1-APP TG rats
WT | TG | |
|---|---|---|
Intrinsic Properties | (n = 7, 9 cells) | (n = 6, 14 cells) |
(3.5-5 months) | ||
Resting membrane | −61.6 ± 2.1 | −63.8 ± 1.7 |
potential (mV) | ||
τ membrane (ms) | 14.3 ± 1.0 | 15.1 ± 1.0 |
Sag Ratio | 0.9 ± 0.01 | 0.9 ± 0.01 |
sEPSCs | (n = 5, 6 cells) | (n = 9, 9 cells) |
(4–4.5 months) | ||
Amplitude (pA) | −14.3 ± 1.1 | −12.8 ± 1.0 |
Frequency (Hz) | 3.5 ± 1.5 | 2.4 ± 0.6 |
mEPSCs | (n = 5, 6 cells) | (n = 9, 9 cells) |
(4–4.5 months) | ||
Amplitude (pA) | −12.1 ± 1.1 | −11.3 ± 1.1 |
Frequency (Hz) | 1.2 ± 0.4 | 1.1 ± 0.3 |
AMPA EPSCs | (n = 15, 23 cells) | (n = 25, 44 cells) |
(3.5-5 months) | ||
PPF (ratio) 50 ms IPI | 1.4 ± 0.1 | 1.5 ± 0.04 |