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Table 2 Baseline synaptic efficacy and paired pulse facilitation (PPF) were not significantly disrupted in anaesthetized pre-plaque 3.5-4 month-old McGill-Thy1-APP TG rats

From: Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

  WT(n = 5) TG(n = 16)
Baseline EPSP 2.0 ± 0.2 1.9 ± 0.1
(50% maximum amplitude, mV)
Stimulation intensity (mA)   
50% max 6.2 ± 0.2 6.3 ± 0.2
75% max 8.0 ± 0.4 8.2 ± 0.2
100% max 13.4 ± 0.8 13.5 ± 0.3
PPF (ratio)   
20 ms IPI 1.6 ± 0.1 1.5 ± 0.05
40 ms IPI 1.7 ± 0.05 1.6 ± 0.1
100 ms IPI 1.5 ± 0.05 1.5 ± 0.05