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Table 2 Baseline synaptic efficacy and paired pulse facilitation (PPF) were not significantly disrupted in anaesthetized pre-plaque 3.5-4 month-old McGill-Thy1-APP TG rats

From: Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

 

WT(n = 5)

TG(n = 16)

Baseline EPSP

2.0 ± 0.2

1.9 ± 0.1

(50% maximum amplitude, mV)

Stimulation intensity (mA)

  

50% max

6.2 ± 0.2

6.3 ± 0.2

75% max

8.0 ± 0.4

8.2 ± 0.2

100% max

13.4 ± 0.8

13.5 ± 0.3

PPF (ratio)

  

20 ms IPI

1.6 ± 0.1

1.5 ± 0.05

40 ms IPI

1.7 ± 0.05

1.6 ± 0.1

100 ms IPI

1.5 ± 0.05

1.5 ± 0.05