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Table 1 Baseline synaptic efficacy and paired pulse facilitation (PPF) were not significantly disrupted in freely behaving pre-plaque 3–6 month-old McGill-Thy1-APP TG rats

From: Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

  Age (month) WT n TG n
Baseline EPSP 3 1.5 ± 0.2 (5) 1.5 ± 0.6 (7)
(50% maximum amplitude, mV) 4 1.2 ± 0.2 (5) 1.2 ± 0.1 (6)
6 1.0 ± 0.3 (5) 0.9 ± 0.3 (6)
Stimulation intensity 3 9.2 ± 0.3 (5) 9.4 ± 0.2 (7)
(50% maximum, mA) 4 9.8 ± 0.2 (5) 9.9 ± 0.3 (6)
  6 10.8 ± 0.6 (5) 10.7 ± 0.3 (6)
Stimulation intensity 3 13.3 ± 0.3 (5) 12.9 ± 0.4 (7)
(maximum, mA) 4 12.2 ± 0.4 (5) 12.0 ± 0.6 (6)
  6 12.8 ± 0.6 (5) 13.1 ± 0.6 (6)
PPF (ratio) 3 1.6 ± 0.1 (5) 1.6 ± 0.1 (7)
40 ms IPI 4 1.6 ± 0.1 (5) 1.6 ± 0.1 (6)
  6 1.5 ± 0.1 (5) 1.5 ± 0.1 (6)