Table 1 Baseline synaptic efficacy and paired pulse facilitation (PPF) were not significantly disrupted in freely behaving pre-plaque 3–6 month-old McGill-Thy1-APP TG rats
Age (month) | WT | n | TG | n | |
|---|---|---|---|---|---|
Baseline EPSP | 3 | 1.5 ± 0.2 | (5) | 1.5 ± 0.6 | (7) |
(50% maximum amplitude, mV) | 4 | 1.2 ± 0.2 | (5) | 1.2 ± 0.1 | (6) |
6 | 1.0 ± 0.3 | (5) | 0.9 ± 0.3 | (6) | |
Stimulation intensity | 3 | 9.2 ± 0.3 | (5) | 9.4 ± 0.2 | (7) |
(50% maximum, mA) | 4 | 9.8 ± 0.2 | (5) | 9.9 ± 0.3 | (6) |
6 | 10.8 ± 0.6 | (5) | 10.7 ± 0.3 | (6) | |
Stimulation intensity | 3 | 13.3 ± 0.3 | (5) | 12.9 ± 0.4 | (7) |
(maximum, mA) | 4 | 12.2 ± 0.4 | (5) | 12.0 ± 0.6 | (6) |
6 | 12.8 ± 0.6 | (5) | 13.1 ± 0.6 | (6) | |
PPF (ratio) | 3 | 1.6 ± 0.1 | (5) | 1.6 ± 0.1 | (7) |
40 ms IPI | 4 | 1.6 ± 0.1 | (5) | 1.6 ± 0.1 | (6) |
6 | 1.5 ± 0.1 | (5) | 1.5 ± 0.1 | (6) |