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Table 2 Expression levels of genes potentially regulating oligodendrocytes and their fold changes in demyelinated inactive versus remyelinated lesions

From: Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

Gene name CWM Remyelinated Demyelinated Active Re/CWMl   Re/De  
  mean SEM mean SEM mean SEM mean SEM ratio p ratio p
PDGFs             
PDGFA 19.38 2.59 31.78 10.91 15.45 4.47 51.82 34.22 1.64 0.61 2.06 0.26
PDGFB 1.23 0.28 1.71 0.30 6.79 2.91 31.65 29.42 1.39 0.26 0.25 0.48
PDGFC 0.52 0.09 1.45 0.47 1.19 0.48 2.56 1.69 2.78 0.038 1.22 0.61
PDGFD 0.14 0.05 0.37 0.22 0.83 0.46 0.08 0.03 2.61 1.00 0.45 0.45
FGFs             
FGF1 39.42 2.61 85.40 11.54 48.15 19.53 58.18 16.80 2.17 0.010 1.77 0.11
FGF2 3.82 0.56 9.23 0.88 10.25 2.62 6.08 0.63 2.41 0.010 0.90 0.91
FGF5 0.01 0.01 0.00 0.00 0.01 0.01 0.00 0.00 0.00* 0.15 0.00* 0.15
FGF8 0.00 0.00 0.06 0.05 0.02 0.01 0.01 0.00 16.25* 0.74 2.69* 0.72
FGF9 0.04 0.02 0.02 0.01 0.87 0.53 0.01 0.00 0.44* 0.71 0.02* 0.066
Semaphorins             
SEMA3A 0.58 0.11 0.77 0.10 1.77 0.75 0.71 0.25 1.32 0.26 0.43 0.35
SEMA3B 6.33 1.73 10.48 4.21 2.82 1.50 5.37 3.57 1.66 0.61 3.72 0.11
SEMA3C 4.84 1.06 7.13 0.75 2.10 0.59 6.13 1.73 1.47 0.17 3.40 0.010
SEMA3D 0.55 0.09 2.18 0.57 1.08 0.37 0.85 0.23 3.94 0.019 2.02 0.11
SEMA3E 0.41 0.04 0.91 0.29 0.49 0.15 0.69 0.23 2.21 0.26 1.84 0.17
SEMA3F 0.02 0.01 0.02 0.01 0.20 0.10 1.91 1.89 0.93* 0.91 0.10* 0.44
SEMA3G 0.23 0.05 0.16 0.06 0.54 0.31 1.18 0.98 0.68 0.48 0.30 0.91
SEMA4A 0.22 0.06 0.21 0.05 1.00 0.36 0.29 0.04 0.95 0.91 0.21 0.067
SEMA4B 2.63 0.31 8.90 2.16 8.46 3.46 18.31 14.74 3.39 0.010 1.05 0.48
SEMA4C 4.49 0.77 8.07 2.81 3.67 0.83 9.90 6.17 1.80 0.26 2.20 0.11
SEMA4D 16.61 3.51 24.36 7.25 4.72 2.38 23.80 11.36 1.47 0.61 5.16 0.019
SEMA4F 0.40 0.04 1.27 0.13 3.09 0.67 4.83 4.19 3.18 0.010 0.41 0.11
SEMA4G 0.35 0.07 0.44 0.13 0.48 0.28 0.89 0.43 1.26 0.61 0.91 0.59
SEMA5A 2.38 0.56 3.06 0.45 3.08 1.07 8.98 7.60 1.28 0.61 0.99 0.91
SEMA5B 0.45 0.09 0.78 0.18 2.34 0.52 1.32 0.53 1.72 0.17 0.33 0.11
SEMA6A 28.24 6.78 45.65 12.14 12.75 3.45 31.24 4.13 1.62 0.26 3.58 0.010
SEMA6B 0.73 0.18 1.95 0.78 9.90 4.74 31.22 30.80 2.67 0.07 0.20 0.17
SEMA6C 0.05 0.01 0.07 0.03 0.13 0.06 0.06 0.02 1.53 0.28 0.54 0.83
SEMA6D 7.30 1.55 13.26 2.93 4.43 0.84 5.70 1.43 1.82 0.11 3.00 0.019
SEMA7A 2.85 0.75 3.91 0.35 0.93 0.50 2.99 1.56 1.37 0.48 4.22 0.019
Chemokines             
CXCL1 0.18 0.07 1.18 0.32 4.46 3.25 1.30 1.04 6.51 0.019 0.27 0.76
CXCL2 0.17 0.08 0.62 0.14 1.10 0.47 3.49 2.96 3.70 0.019 0.56 0.91
CXCL8 0.23 0.06 0.51 0.19 0.71 0.15 0.52 0.42 2.22 0.26 0.71 0.61
CXCL10 0.02 0.01 0.05 0.02 0.04 0.03 0.88 0.47 1.94* 0.76 1.09 0.66
CXCL12 2.51 0.37 3.65 0.70 30.09 23.06 24.58 16.09 1.45 0.35 0.12 0.76
IL6 family             
CNTF 0.19 0.04 0.52 0.11 0.20 0.11 0.69 0.50 2.66 0.019 2.65* 0.069
CLCF1 0.02 0.01 0.16 0.13 0.48 0.23 0.55 0.34 6.62* 0.35 0.34 0.83
CTF1 0.17 0.03 0.44 0.13 0.82 0.29 1.66 1.36 2.59 0.17 0.54 0.61
IL6 0.06 0.02 0.07 0.03 0.38 0.31 0.06 0.02 1.27 0.76 0.19 0.83
IL11 0.01 0.00 0.07 0.05 0.04 0.03 0.02 0.01 5.11* 1.00 1.63 0.91
LIF 0.01 0.00 0.03 0.02 0.76 0.70 0.43 0.37 5.17* 0.40 0.04 1
IGFs             
IGF1 0.35 0.10 0.32 0.12 0.63 0.23 1.46 0.98 0.94 1.00 0.51 0.61
IGF2 0.23 0.01 0.33 0.12 6.04 4.62 1.95 1.23 1.42 0.26 0.06 0.39
Miscellaneous             
CTGF 1.70 0.50 4.53 0.90 13.40 4.85 9.77 7.80 2.67 0.038 0.34 0.26
FIGF 0.25 0.07 0.28 0.07 0.60 0.51 0.29 0.10 1.09 0.76 0.46 0.34
HGF 0.12 0.02 0.37 0.12 0.31 0.14 0.99 0.40 3.05 0.26 1.17 0.45
LINGO1 0.15 0.11 0.77 0.30 1.42 0.50 0.40 0.14 5.18 0.06 0.54 0.61
  1. CWM: Control white matter, Remyelinated: Remyelinated lesion, Demyelinated: Demyelinated inactive lesion, Active: Demyelinated active lesion, Re/CWM and De/Re ratio: remyelinated vs. control white matter and vs. demyelinated inactive lesions, respectively; p value were calculated by 2-sided U tests, unadjusted for multiple testing. p-values < 0.05 are printed in bold. 0.00: Values were below our detection limit, which was 0.01% GAPDH. Specimens analyzed: 6 normal white matter specimens from 4 subjects, 6 demyelinated inactive lesions from 4 subjects, 4 demyelinated active lesions from 3 subjects, and 4 remyelinated lesions from 3 subjects were dissected and used for qPCR analysis. The mean expression values are given as % GAPDH; SEM denotes standard error of the mean. * Ratios may be imprecise since at least one value was below or close to the detection limit.