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Table 1 Expression levels of myelin genes, astrocyte and inflammation markers in MS lesions and their fold changes in demyelinated inactive versus remyelinated lesions

From: Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

Gene name

CWM

Remyelinated

Demyelinated

Active

Re/CWM

 

Re/De

 
 

mean

SEM

mean

SEM

mean

SEM

mean

SEM

ratio

p

ratio

p

Myelin proteins

            

CNP

333.38

75.99

539.31

253.33

50.77

20.00

228.49

77.20

1.62

0.48

10.62

0.0095

MAG

57.21

10.00

65.82

11.80

11.57

6.28

43.18

4.67

1.15

0.76

5.69

0.019

MBP

40.84

7.40

41.85

13.02

6.91

2.49

107.43

83.98

1.02

0.76

6.06

0.0095

MOBP

350.12

84.65

422.56

164.85

34.10

18.05

316.04

145.56

1.21

0.91

12.39

0.0095

MOG

61.33

15.60

90.21

13.05

10.87

5.26

50.26

14.17

1.47

0.26

8.30

0.0095

OMG

48.67

13.67

86.83

32.00

13.87

4.27

20.85

4.88

1.78

0.35

6.26

0.019

PLP1

2239.24

486.85

3434.69

397.98.

400.80

143.30

1917.75

252.49

1.53

0.11

8.57

0.0095

Astrocyte and inflammation markers

            

GFAP

890.74

123.37

2713.08

451.88

4715.80

1637.94

11466.90

9726.52

3.05

0.010

0.58

0.91

CD68

5.57

0.68

11.24

1.00

12.07

3.67

62.60

33.16

2.02

0.010

0.93

1

HLA-DRA

21.83

6.34

29.63

8.83

20.66

4.05

79.79

7.09

1.36

0.48

1.43

0.35

IL1B

0.17

0.02

0.14

0.06

0.19

0.10

0.33

0.12

0.80

0.76

0.71

1

IL10

0.13

0.03

0.24

0.06

0.07

0.03

0.71

0.40

1.82

0.26

3.29

0.040

TNFSF13B (BAFF)

0.71

0.17

2.04

0.64

0.95

0.27

2.88

1.10

2.88

0.067

2.15

0.26

TGFB1

5.32

0.99

12.68

2.10

15.03

6.22

106.86

97.86

2.38

0.010

0.84

1

TGFB2

2.02

0.16

5.08

0.86

7.35

2.66

5.36

0.63

2.52

0.010

0.69

0.76

TGFB3

4.73

0.70

9.75

4.75

3.09

0.77

8.10

5.37

2.06

0.35

3.15

0.067

  1. CWM: Control white matter, Remyelinated: Remyelinated lesion, Demyelinated: Demyelinated inactive lesion, Active: Demyelinated active lesion, Re/CWM and De/Re ratio: Remyelinated vs. control white matter and vs. demyelinated inactive lesions, respectively; p value were calculated by 2-sided U tests, unadjusted for multiple testing. p-values < 0.05 are printed in bold. Specimens analyzed: Six normal white matter specimens from 4 subjects, 6 demyelinated inactive lesions from 4 subjects, 4 demyelinated active lesions from 3 subjects, and 4 remyelinated lesions from 3 subjects were dissected and used for qPCR analysis. The mean expression values are given as % GAPDH; SEM denotes standard error of the mean.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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