|
Gene name
|
CWM
|
Remyelinated
|
Demyelinated
|
Active
|
Re/CWM
| |
Re/De
| |
|---|
| |
mean
|
SEM
|
mean
|
SEM
|
mean
|
SEM
|
mean
|
SEM
|
ratio
|
p
|
ratio
|
p
|
|---|
|
Myelin proteins
| | | | | | | | | | | | |
|
CNP
|
333.38
|
75.99
|
539.31
|
253.33
|
50.77
|
20.00
|
228.49
|
77.20
|
1.62
|
0.48
|
10.62
|
0.0095
|
|
MAG
|
57.21
|
10.00
|
65.82
|
11.80
|
11.57
|
6.28
|
43.18
|
4.67
|
1.15
|
0.76
|
5.69
|
0.019
|
|
MBP
|
40.84
|
7.40
|
41.85
|
13.02
|
6.91
|
2.49
|
107.43
|
83.98
|
1.02
|
0.76
|
6.06
|
0.0095
|
|
MOBP
|
350.12
|
84.65
|
422.56
|
164.85
|
34.10
|
18.05
|
316.04
|
145.56
|
1.21
|
0.91
|
12.39
|
0.0095
|
|
MOG
|
61.33
|
15.60
|
90.21
|
13.05
|
10.87
|
5.26
|
50.26
|
14.17
|
1.47
|
0.26
|
8.30
|
0.0095
|
|
OMG
|
48.67
|
13.67
|
86.83
|
32.00
|
13.87
|
4.27
|
20.85
|
4.88
|
1.78
|
0.35
|
6.26
|
0.019
|
|
PLP1
|
2239.24
|
486.85
|
3434.69
|
397.98.
|
400.80
|
143.30
|
1917.75
|
252.49
|
1.53
|
0.11
|
8.57
|
0.0095
|
|
Astrocyte and inflammation markers
| | | | | | | | | | | | |
|
GFAP
|
890.74
|
123.37
|
2713.08
|
451.88
|
4715.80
|
1637.94
|
11466.90
|
9726.52
|
3.05
|
0.010
|
0.58
|
0.91
|
|
CD68
|
5.57
|
0.68
|
11.24
|
1.00
|
12.07
|
3.67
|
62.60
|
33.16
|
2.02
|
0.010
|
0.93
|
1
|
|
HLA-DRA
|
21.83
|
6.34
|
29.63
|
8.83
|
20.66
|
4.05
|
79.79
|
7.09
|
1.36
|
0.48
|
1.43
|
0.35
|
|
IL1B
|
0.17
|
0.02
|
0.14
|
0.06
|
0.19
|
0.10
|
0.33
|
0.12
|
0.80
|
0.76
|
0.71
|
1
|
|
IL10
|
0.13
|
0.03
|
0.24
|
0.06
|
0.07
|
0.03
|
0.71
|
0.40
|
1.82
|
0.26
|
3.29
|
0.040
|
|
TNFSF13B (BAFF)
|
0.71
|
0.17
|
2.04
|
0.64
|
0.95
|
0.27
|
2.88
|
1.10
|
2.88
|
0.067
|
2.15
|
0.26
|
|
TGFB1
|
5.32
|
0.99
|
12.68
|
2.10
|
15.03
|
6.22
|
106.86
|
97.86
|
2.38
|
0.010
|
0.84
|
1
|
|
TGFB2
|
2.02
|
0.16
|
5.08
|
0.86
|
7.35
|
2.66
|
5.36
|
0.63
|
2.52
|
0.010
|
0.69
|
0.76
|
|
TGFB3
|
4.73
|
0.70
|
9.75
|
4.75
|
3.09
|
0.77
|
8.10
|
5.37
|
2.06
|
0.35
|
3.15
|
0.067
|
- CWM: Control white matter, Remyelinated: Remyelinated lesion, Demyelinated: Demyelinated inactive lesion, Active: Demyelinated active lesion, Re/CWM and De/Re ratio: Remyelinated vs. control white matter and vs. demyelinated inactive lesions, respectively; p value were calculated by 2-sided U tests, unadjusted for multiple testing. p-values < 0.05 are printed in bold. Specimens analyzed: Six normal white matter specimens from 4 subjects, 6 demyelinated inactive lesions from 4 subjects, 4 demyelinated active lesions from 3 subjects, and 4 remyelinated lesions from 3 subjects were dissected and used for qPCR analysis. The mean expression values are given as % GAPDH; SEM denotes standard error of the mean.
