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Table 1 Expression levels of myelin genes, astrocyte and inflammation markers in MS lesions and their fold changes in demyelinated inactive versus remyelinated lesions

From: Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

Gene name CWM Remyelinated Demyelinated Active Re/CWM   Re/De  
  mean SEM mean SEM mean SEM mean SEM ratio p ratio p
Myelin proteins             
CNP 333.38 75.99 539.31 253.33 50.77 20.00 228.49 77.20 1.62 0.48 10.62 0.0095
MAG 57.21 10.00 65.82 11.80 11.57 6.28 43.18 4.67 1.15 0.76 5.69 0.019
MBP 40.84 7.40 41.85 13.02 6.91 2.49 107.43 83.98 1.02 0.76 6.06 0.0095
MOBP 350.12 84.65 422.56 164.85 34.10 18.05 316.04 145.56 1.21 0.91 12.39 0.0095
MOG 61.33 15.60 90.21 13.05 10.87 5.26 50.26 14.17 1.47 0.26 8.30 0.0095
OMG 48.67 13.67 86.83 32.00 13.87 4.27 20.85 4.88 1.78 0.35 6.26 0.019
PLP1 2239.24 486.85 3434.69 397.98. 400.80 143.30 1917.75 252.49 1.53 0.11 8.57 0.0095
Astrocyte and inflammation markers             
GFAP 890.74 123.37 2713.08 451.88 4715.80 1637.94 11466.90 9726.52 3.05 0.010 0.58 0.91
CD68 5.57 0.68 11.24 1.00 12.07 3.67 62.60 33.16 2.02 0.010 0.93 1
HLA-DRA 21.83 6.34 29.63 8.83 20.66 4.05 79.79 7.09 1.36 0.48 1.43 0.35
IL1B 0.17 0.02 0.14 0.06 0.19 0.10 0.33 0.12 0.80 0.76 0.71 1
IL10 0.13 0.03 0.24 0.06 0.07 0.03 0.71 0.40 1.82 0.26 3.29 0.040
TNFSF13B (BAFF) 0.71 0.17 2.04 0.64 0.95 0.27 2.88 1.10 2.88 0.067 2.15 0.26
TGFB1 5.32 0.99 12.68 2.10 15.03 6.22 106.86 97.86 2.38 0.010 0.84 1
TGFB2 2.02 0.16 5.08 0.86 7.35 2.66 5.36 0.63 2.52 0.010 0.69 0.76
TGFB3 4.73 0.70 9.75 4.75 3.09 0.77 8.10 5.37 2.06 0.35 3.15 0.067
  1. CWM: Control white matter, Remyelinated: Remyelinated lesion, Demyelinated: Demyelinated inactive lesion, Active: Demyelinated active lesion, Re/CWM and De/Re ratio: Remyelinated vs. control white matter and vs. demyelinated inactive lesions, respectively; p value were calculated by 2-sided U tests, unadjusted for multiple testing. p-values < 0.05 are printed in bold. Specimens analyzed: Six normal white matter specimens from 4 subjects, 6 demyelinated inactive lesions from 4 subjects, 4 demyelinated active lesions from 3 subjects, and 4 remyelinated lesions from 3 subjects were dissected and used for qPCR analysis. The mean expression values are given as % GAPDH; SEM denotes standard error of the mean.