Figure 7

FGF1 decelerate s differentiation of monocultured oligodendrocytes. a FGF1 does not affect proliferation of primary murine OPCs but b decelerates the differentiation into myelinating oligodendrocytes as determined by morphology; Two-way ANOVA with Bonferroni post correction **p < 0.01; *p < 0.05. The expression of myelin-associated genes was assessed by quantitative RT-PCR on samples from OPCs (6 h), immature (24 h) and mature cells (48 h). The expression levels of c Mbp, d Mag and in e Mog are reduced due to increasing FGF1 concentrations; one-way ANOVA with Bonferroni post correction *** p < 0.001 **P < 0.01; *P = <0.05; error bars represent SEM from three independent experiments.